Selected
publications

Peer-reviewed

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Chen S*, Birey F*, Li MY, Revah O, Levy R, Thete MV, Reis N, Kaganovsky K, Onesto M, Sakai N, Hudacova Z, Hao J, Meng X, Nishino S, Huguenard H, Pasca SP.
Nature (2024) *equal contribution.
Cover Article
Open Access
Preview by Velasco

Editorial: Improving in vitro modeling of the human brain with future brain organoids.

Barral S, Xiang Y and Birey F.
Frontiers in Molecular Neuroscience (2022)
Open Access

Maturation and circuit integration of transplanted human cortical organoids.

Revah O*, Gore F*, Kelley KW*, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR, Deisseroth K, Pasca SP.
Nature (2022) *equal contribution.
Open Access

Imaging neuronal migration and network activity in human forebrain assembloids.

Birey F and Pasca SP.
STAR Protocols (2022).
[PDF]

Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy Syndrome.

Birey F, Li M, Gordon A, Thete M, Valencia A, Revah O, Pasca AM, Geschwind D, Pasca SP.
Cell Stem Cell (2022).
Cover article [PDF]
Preview by Fernando and Brennand

Primate cell fusion disentangles gene regulatory divergence in neural development.

Agoglia RM, Sun D, Birey F, Yoon SJ, Miura Y, Sabatini K, Pasca SP, Fraser H.
Nature (2021).
[PDF]

Human neuromodulatory assembloids to study serotonin signaling and disease.

Kanton S*, Meng X*, Dong C*, Birey F, Wang D, Reis N, Yoon SJ, Kim JI, McQueen JP, Sakai N, Nishino S, Huguenard JR, Pașca SP.
BioRxiv (2026) *equal contribution.

Human-specific tandem repeat in CACNA1C modulates responses to neuronal stimulation

Song JHT*, Birey F*, Hung TC, Hall NAL, Guenther CA, Chen X, Alkuraya IF, Tunbridge EM, Haerty W, Pasca SP, Kingsley DM
BioRxiv (2025) *equal contribution.

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals.

Liu J*, Kim YS*, Richardson CE*, Tom A*, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang X, Fenno LF, Tok JBH, Pasca SP, Shen K, Bao Z, Deisseroth K.
Science (2020). *equal contribution.
[PDF]

Generation of human striatal organoids and cortico-striatal assembloids from pluripotent stem cells.

Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete M, Park JY, Puno A, Porteus M, Pasca SP.
Nature Biotechnology (2020).
[PDF]

Generation and Assembly of  Human Brain Region-Specific 3D Cultures.

Sloan SA*, Andersen J*, Pasca AM*, Birey F*, Pasca SP.
Nature Protocols (2018). *equal contribution.
Cover article [PDF] F1000

Assembly of functionally integrated  human forebrain spheroids

Birey F*, Andersen J*, Makinson CD*, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Pasca SP.
Nature (2017). *equal contribution.
[PDF] 2017 NIH Research Highlights F1000 Stanford Press Release

Human astrocyte maturation captured in 3D cortical spheroids derived from pluripotent stem cells.

Sloan SA, Darmanis S*, Huber N*, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA*, Pasca SP*.
Neuron (2017). *equal contribution.
[PDF] F1000 NIH Press Release

Nondestructive nanostraw intracellular sampling  for longitudinal cell monitoring.

Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiza SA, Hand CM, Santiago JG, Pasca SP, Wu JC, and Melosh NA.
PNAS (2017).
[PDF] 2017 Cozzarelli Prize in Engineering and Applied Sciences

Preprints

Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity.

Puno A, Michno WP, Li L, Everitt A, McCluskey K, Htun S, Nagar D, Choi JB, Dai Y, Park S, Gurwitz E, Willsey JA, Birey F, Pasca AM.
eLife (2026) *equal contribution.

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway.

Kim JI*, Miura Y*, Li MY, Revah O, Selvaraj S, Birey F, Meng X, Thete MV, Pavlov SD, Andersen J, Pasca AM, Porteus MH, Huguenard JR and Pasca SP.
Neuron (2024) *equal contribution.

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Enhanced electrophysiological recordings in acute brain slices, spheroids, and organoids using 3D high-density multielectrode arrays.

Mapelli L, Di Domenico D, Sciacca G, Mainardi F, Ottaviani A, Monteverdi A, Tedesco M, Battaglia CR, Tritto S, Gandolfo M, Imfeld K, Kiderlen S, Krainer L, Cervetto C, Marcoli M, Sing A, Andersen J, Birey F, Sloan SA, Maccione A, D'Angelo E.
PLoS One (2025)

Measuring Electrophysiological Activity in Acute Brain Slices, Spheroids, and Organoids Using 3D High-Density Multielectrode Arrays.

Pali E, Pellavio G, Conforti M, Sarkissian AA, Aliya B, Sciacca G, Wariyar SS, Mainardi F, Tedesco M, Verduci I, Cadiao G, Cervetto C, Andersen J, Birey F, Maccione A, D'Angelo E, Mapelli L.
Bio-protocols (2026) *equal contribution.